METHOD TO IDENTIFY COMPOUNDS ABLE TO BIND TO THE ROSSMANN FOLD OF C-TERMINAL-BINDING PROTEINS, IDENTIFIED COMPOUNDS AND MEDICAL USES THEREOF

摘要

The invention refers to a method for identifying an anti-tumoral and/or anti-proliferative and/or an inhibitor of the fission machinery involved in mitotic Golgi partitioning and/or a molecule modulator of CtBP corepressor activity by testing their affinity binding for the Rossmann fold of C-terminal-binding proteins (CtBPs); to said identified molecules and to the use thereof as anti-proliferative and/or anti tumoral agents.

主权项

1. A method for identifying a molecule acting as an anti-tumoral and/or an anti-proliferative and/or an inhibitor of the fission machinery involved in mitotic Golgi partitioning and/or a modulator of C-terminal-binding proteins (CtBPs) corepressor activity, comprising the steps of:
assaying candidate molecules for their affinity binding for the Rossmann fold of C-terminal-binding proteins (CtBPs); selecting molecules having an high affinity binding for the Rossmann fold of C-terminal-binding proteins (CtBPs); testing such high affinity binding molecules for their capacity of inhibiting proliferation and/or inducing an apoptotic response in a cell system.