| 主权项 |
1. A compound of the Formula I:
V—V1-V2-R—W′, wherein V is ONO2; or V is H or absent when one of V1, V2, R or W′ is ONO2; or V is H or is absent when W′ is -A-C′-B′-D and one of A, C′, B′ or D is ONO2; V1 if present is selected from alkyl, amide, alcohol, ester, heteroalkyl, aryl, heteroaryl, —S-alkyl-, —O-alkyl, —N-alkyl, and —NH-alkyl-; V2 if present is selected from alkyl, amide, alcohol, ester, heteroalkyl, —S— alkyl-, —O—, alkyl, —N-alkyl, —NH-alkyl, —C(O)O—, O, aryl, heteroaryl, arylalkyl, heteroarylalkyl, arylalkoxy, heteroarylalkoxy, aryloxy and heteroaryloxy; R is selected from aryl, heteroaryl, alkyl and heteroalkyl; W′ is -A-C′-B′-D wherein
A is selected from a direct bond, O, —C(=D1)- or —(CH2)lN(D2)-, wherein l is an integer between 0 and 3;C′ is a direct bond,B′ is selected from a direct bond, O, —N(D2)-, —N(D1)(D2)-, —C(D1)(D2)-, —(CH2)l−), alkyl, aryl, heteroalkyl, heteroarl, alkoxy, aryloxy, heteroarylalkoxy, heteroaryloxy —NH-alkyl-, —NHSO2—, wherein l is an integer between 0 and 3;D1 is selected from O, S, aryl, ND2, and NSO2D2D2 is selected from H, C(═NH), OD3, O, alcohol, alkyl, amine, heteroalkyl, aryl, heteroaryl, and SO2alkyl;
D3 is H or NO2; andD is selected from a carbocyclic ring, a heterocyclic ring, an aromatic ring, a heteroaromatic ring, a bicyclic ring, a heterobicyclic ring, a tricyclic ring, a heterotricyclic ring, a polycyclic ring or a heteropolycyclic ring; or D is wherein G is selected from CH, C(CH3), C(CN) and N;L, K′ and J are each independently selected from (CH2)n, (CH3)2, C═O, O, —CHOH, C(CH3)OM1, C(CH2)n(X)Y, C(K1)K2, NM1, SO2, SO and S;n is an integer from 0 to 7;K1 and K2 are each independently selected from CH3, halogen, OM1, CONM1M2, NM1M2, alkyl, alkylNM1M2, aryl, alcohol, heteroalkyl and heteroaryl,M1 is selected from H, alkyl, SO2(M2), C(O)M2, and CONHM2,M2 is selected from H, alkyl, NM3M4, OM5 and M3,M4 and M5 are each independently selected from H, OH, ONO2, alcohol and alkyl, andX and Y are each independently selected from H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8, —C≡CX8;
X1 and X2 are independently selected from H and alkyl, orX1 and X2 together are part of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, orX1 and X2 together are part of an imide ring having 5 to 6 members,X3 is selected from H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl, and alkyl-NX1X2,X4, X5, and X6 are independently selected from H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7, and O-alkyl-X7,X7 is selected from H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H and COX8,X8 is selected from H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring, and CX9═CHX10 X9 and X10 are independently selected from H and alkyl;m is an integer from 0 to 7;j is an integer from 0 to 6; andk is an integer from 0 to 2; or D is wherein G, L and J is each independently selected from CH and N; or D is selected from wherein X and Y are independently selected from H, halogen, CF3, CF2H, N3, NCS, CN, NO2, NX1X2, OX3, SX3, OAc, OSO2X3, O-acyl, S-acyl, SO2-alkyl, SO-alkyl, SC(CH3)2COOX8, OC(CH3)2COOX8, C(CH3)2COOX8, Si(alkyl)3, alkyl-CN, O-aroyl, O(CH2)jOX3, O(CH2)jNX1X2, NH-acyl, NH-aroyl, CHO, C(halogen)3, COOX3, SO3H, SO2NX1X2, CONX1X2, NHC(O)O-alkyl, NHSO2-alkyl, alkoxy, alkyl, alcohol, alkylmercapto, alkylamino, di-alkylamino, alkylsulfinyl or alkylsulfonyl, CX4X5X6, —CH═CHX8 and —C≡CX8; X1 and X2 are independently selected from H and alkyl, or X1 and X2 together are members of a heterocyclic ring having 4 to 7 ring members and optionally one additional heteroatom selected from O, N or S, or X1 and X2 together are members of an imide ring having 5 to 6 members, X3 is selected from H, alkyl, NO2, (CH2)mCN, hydroxyloweralkyl and alkyl-NX1X2, X4, X5, and X6 are independently selected from H, alkyl, carbocyclic ring, hydroxyloweralkyl, alkyl-OH, halogen, CN, SNO, S(SO2)alkyl, NX1X2, COOX3, CONX3, OX7 and O-alkyl-X7, X7 is selected from H, alkyl, NO2, NO, P(O)(OX8)2, PH(O)(OX8), S(O)kN(alkyl)2, S(O)kX8, S(O)kOX8, COOX8, CONX8, SO3H and COX8, X8 is selected from H, alkyl, carbocyclic ring, heterocyclic ring, aromatic ring, heteroaromatic ring and —CX9═CHX10, X9 and X10 are independently selected from H and alkyl; m is an integer from 0 to 7; j is an integer from 0 to 6; k is an integer from 0 to 2; and W′ is H or alkyl; or D is selected from a carbocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a carbocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, a heterocyclic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms, an aromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms, a heteroaromatic ring having 6 ring atoms fused to a heterocyclic ring having from 5 to 7 ring atoms or a heteroaromatic ring having 6 ring atoms fused to a heteroaromatic ring having from 5 to 7 ring atoms; or D is selected from H, OH, ONO2, alkyl, amide, amine, alcohol and ester. |
