发明名称 |
NEW USE OF 2-(4-(BENZO[D]THIAZOLE-2-YL)-2-BROMO-6-METHOXYPHENOXY) ACETIC ACID |
摘要 |
Disclosed is a new use of a 2-(4-(benzo[d]thiazole-2-yl)-2-bromo-6-methoxyphenoxy) acetic acid. In particular, the 2-(4-(benzo[d]thiazole-2-yl)-2-bromo-6-methoxyphenoxy) acetic acid of the present invention has the effect of MIF inhibitor, can significantly inhibit the release of inflammatory cytokines (TNF-α and NO) induced by LPS, and can also inhibit the chemotactic migration of macrophages caused by MIF and also the phosphorylation of ERK1/2, so that same can be used to prepare an anti-inflammatory drug related to MIF. |
申请公布号 |
WO2017000266(A1) |
申请公布日期 |
2017.01.05 |
申请号 |
WO2015CN83010 |
申请日期 |
2015.06.30 |
申请人 |
ZHANGJIAGANG INSTITUTE OF INDUSTRIAL TECHNOLOGIES SOOCHOW UNIVERSITY |
发明人 |
ZHEN, Xuechu;HOU, Tingjun;XU, Lei;ZHANG, Yu;ZHEN, Longtai |
分类号 |
A61K31/428;A61P9/10;A61P19/02;A61P29/00 |
主分类号 |
A61K31/428 |
代理机构 |
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主权项 |
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