TRANSDERMAL DRUG DELIVERY SYSTEMS FOR LEVONORGESTREL AND ETHINYL ESTRADIOL

摘要

Described are transdermal drug delivery systems for the transdermal administration of levonorgestrel and ethinyl estradiol, comprising an acrylic polymer matrix. Methods of making and using such systems also are described.

主权项

1. A transdermal drug delivery system for the transdermal delivery of levonorgestrel and ethinyl estradiol in the form of a flexible finite system for topical application, comprising a polymer matrix comprising levonorgestrel, ethinyl estradiol, an acrylic polymer that comprises a hydroxy functional acrylic polymer, a humectant, a first enhancer selected from the group consisting of glyceryl monooleate, dipropylene glycol, and methyl laurate, a second enhancer different from the first enhancer and selected from the group consisting of glyceryl monooleate, dipropylene glycol, methyl laurate, diethylene glycol monoethyl ether, and dimethyl isosorbide, and, optionally, and a third enhancer different from the first and second enhancers and selected from the group consisting of glyceryl monooleate, dipropylene glycol, methyl laurate, diethylene glycol monoethyl ether, and dimethyl isosorbide.