DEGRADATION OR NEUTRALIZATION OF APOBEC3B BY SIMIAN IMMUNODEFICIENCY VIRUS VIF

摘要

In one aspect, a method involves providing tumor cells, providing a polynucleotide encoding at least a portion of a simian immunodeficiency virus (SIV) Vif gene, and introducing the polynucleotide into the tumor cells. In another aspect, a method involves introducing into a cell a polynucleotide encoding a simian immunodeficiency virus (SIV) Vif, wherein expression of the SIV Vif in the cell results in modulation of the functional activity of APOBEC3B in the cell. In either aspect, the SIV Vif protein can include SIVmac239 Vif, SIVsmCFU212 Vif, SIVsmPG Vif, SIVsmPBj Vif, SIVsmE041 Vif, SIVstm Vif, SIVmac142 Vif, SIVmfa186 Vif, SIVmne07 Vif, or SIVsmE543 Vif. In some of these embodiments, the polynucleotide is codon-optimized for expression in a human cell.