cGAP-PNA MULTIVALENT PEPTIDE NUCLEIC ACID LIGAND DISPLAY

摘要

Described herein are compositions composed of peptide nucleic acid strands. In some aspects the peptide nucleic acid strands are complementary to at least a portion of another peptide nucleic acid strand that may have one or more gamma substituents, where the ratio of PNA strands is least 1:1. Certain gamma substituents are capable of effecting attachment of a PNA strand to a cell. The disclosure also concerns construction of nanostructure platforms and vaccines and use of the inventive compositions in inhibiting disease states in mammals.

主权项

1. A macromolecule comprising a plurality of linked peptide nucleic acid (PNA) strands, wherein each of said strands is independently composed of a plurality of nucleobase subunits, and each PNA strand is covalently linked to at least one other PNA strand via an amino acid linker, wherein the amino acid linker is a biological amino acid linker or a N,N-dimethyl-lysine linker.