| 摘要 |
The present invention relates to a micro-fluidic device for use in a micro-fluidic system. A rigid base structure is provided with a flexible membrane. An external magnetic driver moves from a first position to a second position underneath the micro-fluidic device whilst applying a magnetic field. A droplet containing magnetic particles will be attracted to the external magnetic driver. The flexible membrane is thin, and therefore the micro-fluidic device can be brought closer to the external magnetic driver, thus increasing the magnetic force incident on the fluid drop. A force will be exerted on the flexible membrane, so deflecting the flexible membrane, thus bringing the droplet containing magnetic particles closer to the external magnetic driver. The effect of the increased magnetic field is to increase the packing density of the magnetic droplet. Therefore, a droplet with higher integrity, and less susceptible to splitting, may be moved through the micro-fluidic device. |
| 主权项 |
1. A micro-fluidic device for fluidic sample analysis, arranged to be positioned in a micro-fluidic controller comprising an external magnetic driver, comprising:
a base structure; a flexible membrane; a micro-fluidic transition path limited by, at a bottom side, at least a portion of the base structure and by, at a top side, at least a portion of the flexible membrane, and extending between at least one inlet to be in communication with a first region and at least one outlet to be in communication with a second region; and wherein the microfluidic device is adapted such that, once in position in the micro-fluidic controller, the flexible membrane is placed in proximity to said external magnetic driver;
wherein the micro-fluidic device further comprises: a plurality of magnetic particles (i) arranged to be put in contact and included thereafter in a fluid included in the microfluidic device or (ii) already included in the fluid and the micro-fluidic device further comprises this fluid; and wherein the micro-fluidic device is configured so that when the fluid containing the plurality of magnetic particles approaches or is within the micro-fluidic transition path and a magnetic force is applied by the external magnetic driver near the flexible membrane, at least a part of the magnetic particles are moved away from the base structure towards the flexible membrane, and wherein the flexible membrane is deflectable away from the base structure such that, when the flexible membrane is deflected, at least a part of the magnetic particles can be located, without the fluid or with a part of the fluid, beyond the in rest position of the flexible membrane; and wherein the micro-fluidic device is arranged such that the magnetic particles can move, without fluid or with only a part of the fluid, through the micro-fluidic transition path when an external magnetic driver applies a magnetic force in proximity to the micro-fluidic transition path. |
