发明名称 |
COMPOSITIONS AND METHODS FOR IMPROVED ENCAPSULATION OF FUNCTIONAL PROTEINS IN POLYMERIC VESICLES |
摘要 |
Methods of preparing polymersome-encapsulated functional protein suspensions may include thermally blending an amount of a block copolymer with an amount of a low molecular weight polyethylene glycol (PEG) for at least 30 minutes, mixing and cooling a resulting PEG/polymer formulation to room temperature, adding an aliquot of a solution of the functional protein to a sample containing the PEG/polymer formulation, and performing at least three dilution steps in which polymersomes that are generated are progressively saturated with the functional protein. The aliquot of the solution of the functional protein added may have a to the PEG/polymer sample of around 0.5:1 to 1.5:1 by volume, and the thermal blending may be performed at 90-100 °C. |
申请公布号 |
WO2017004498(A1) |
申请公布日期 |
2017.01.05 |
申请号 |
WO2016US40657 |
申请日期 |
2016.07.01 |
申请人 |
GHOROGHCHIAN, P. Peter;YEWLE, Jivan Namdeo |
发明人 |
GHOROGHCHIAN, P. Peter;YEWLE, Jivan Namdeo |
分类号 |
A61K9/107;A61K38/42;A61K47/10 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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