| 主权项 |
1. A compound that has the structure of Formula (A), or a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, diastereomeric mixture, individual enantiomers or prodrug thereof: wherein: A1 and A2 are independently N or CRA, provided that A1 and A2 are not N at the same time;
each RA is independently hydrogen, unsubstituted or substituted C1-C4alkyl, unsubstituted or substituted C1-C4fluoroalkyl, unsubstituted or substituted C1-C4alkoxy, unsubstituted or substituted C1-C4fluoroalkoxy, —CN, —OH, —CO2R17, —C(═O)NR17R18, —NR17R18, —NR17C(═O)NHR18, —NR17C(═O)(C1-C4alkyl), —C(═NOR17)R18, —SR17, —S(═O)(C1-C4alkyl), —SO2(C1-C4alkyl), or —SO2NR17R18; B1 and B2 are independently N or CRB, provided that B1 and B2 are not N at the same time;
each RB is independently hydrogen, unsubstituted or substituted C1-C4alkyl, unsubstituted or substituted C1-C4fluoroalkyl, unsubstituted or substituted C1-C4alkoxy, unsubstituted or substituted C1-C4fluoroalkoxy, —CN, —OH, —CO2R17, —C(═O)NR17R18, —NR17R18, —NR17C(═O)NHR18, —NR17C(═O)(C1-C4alkyl), —C(═NOR17)R18, —SR17, —S(═O)(C1-C4alkyl), —SO2(C1-C4alkyl), or —SO2NR17R18; R1 is hydrogen, unsubstituted or substituted C1-C6alkyl, unsubstituted or substituted monocyclic carbocycle, unsubstituted or substituted bicyclic carbocycle, unsubstituted or substituted monocyclic heterocycle, unsubstituted or substituted bicyclic heterocycle, —(C1-C4alkylene)-(unsubstituted or substituted monocyclic carbocycle or unsubstituted or substituted bicyclic carbocycle), or —(C1-C4 alkylene)-(unsubstituted or substituted monocyclic heterocycle or unsubstituted or substituted bicyclic heterocycle), wherein if R1 is substituted then R1 is substituted with 1-2 R13 and 0-2 R14; R2 is hydrogen, unsubstituted or substituted C1-C6alkyl, unsubstituted or substituted monocyclic carbocycle, unsubstituted or substituted bicyclic carbocycle, unsubstituted or substituted monocyclic heterocycle, unsubstituted or substituted bicyclic heterocycle, —(C1-C4 alkylene)-(unsubstituted or substituted monocyclic carbocycle or unsubstituted or substituted bicyclic carbocycle), or —(C1-C4 alkylene)-(unsubstituted or substituted monocyclic heterocycle or unsubstituted or substituted bicyclic heterocycle), wherein if R2 is substituted then R2 is substituted with 1-2 R15 and 0-2 R16; R3 and R4 are independently hydrogen, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C1-C6 fluoroalkyl, or unsubstituted or substituted C3-C6 cycloalkyl, wherein any substituted group of R3 and R4 is substituted with 1-4 R12; or R3 and R4 are taken together with the nitrogen atom with to which they are attached to form an unsubstituted or substituted monocyclic 4- to 7-membered heterocyclic ring or an unsubstituted or substituted bicyclic 9- to 12-membered heterocyclic ring, wherein if the heterocyclic ring is substituted then the heterocyclic ring is substituted with 1-4 R12; R5, R6, R7, R8, R10, and R11 are each independently selected from the group consisting of hydrogen, unsubstituted or substituted C1-C6 alkyl, and unsubstituted or substituted C1-C6 fluoroalkyl, unsubstituted or substituted monocyclic carbocycle, unsubstituted or substituted bicyclic carbocycle, unsubstituted or substituted monocyclic heterocycle, unsubstituted or substituted bicyclic heterocycle, —(C1-C4 alkylene)-(unsubstituted or substituted monocyclic carbocycle or unsubstituted or substituted bicyclic carbocycle), or —(C1-C4 alkylene)-(unsubstituted or substituted monocyclic heterocycle or unsubstituted or substituted bicyclic heterocycle), wherein if R5, R6, R7, R8, R10, and R11 is substituted then R5, R6, R7, R8, R10, and R11 is substituted with 1-2 R15 and 0-2 R16; X is NR9, O, or CR9R19; R9 is hydrogen, unsubstituted or substituted C1-C6 alkyl, or unsubstituted or substituted benzyl, wherein if R9 is substituted then R9 is substituted with 1-4 R12; R19 is hydrogen, or unsubstituted or substituted C1-C6 alkyl, wherein if R19 is substituted then R19 is substituted with 1-4 R12; or R4 and any one of R5, R7, R9, or R11 are taken together with the intervening atoms to which they are attached to form an unsubstituted or substituted monocyclic 4- to 7-membered heterocyclic ring or an unsubstituted or substituted bicyclic 9- to 12-membered heterocyclic ring, wherein if the heterocyclic ring is substituted then the heterocyclic ring is substituted with 1-4 R12; or R5 and R6 are taken together with the carbon atom with to which they are attached to form an unsubstituted or substituted monocyclic 4- to 7-membered carbocyclic ring, wherein if the carbocyclic ring is substituted then the carbocyclic ring is substituted with 1-4 R12; or R5 and any one of R7, R9, or R11 are taken together with the intervening atoms to which they are attached to form an unsubstituted or substituted monocyclic 4- to 7-membered heterocyclic ring or an unsubstituted or substituted bicyclic 9- to 12-membered heterocyclic ring, wherein if the heterocyclic ring is substituted then the heterocyclic ring is substituted with 1-4 R12; or R7 and one of R9 or R11 are taken together with the intervening atoms to which they are attached to form an unsubstituted or substituted monocyclic 4- to 7-membered heterocyclic ring or an unsubstituted or substituted bicyclic 9- to 12-membered heterocyclic ring, wherein if the heterocyclic ring is substituted then the heterocyclic ring is substituted with 1-4 R12; or R9 and R11 are taken together with the intervening atoms to which they are attached to form an unsubstituted or substituted monocyclic 4- to 7-membered heterocyclic ring or an unsubstituted or substituted bicyclic 9- to 12-membered heterocyclic ring, wherein if the heterocyclic ring is substituted then the heterocyclic ring is substituted with 1-4 R12; each R12 is independently halogen, heterocycle, C1-C4alkyl, C1-C4alkoxy, C1-C4hydroxyalkyl, C1-C4aminoalkyl, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, —CN, —OR17, —CO2R17, —C1-C4alkylCO2R17, —C(═O)NR17R18, —NR17R18, —NR17C(═O)NHR18, —NR17C(═O)R18, —C(═NOR17)R18, —SR17, —S(═O)(C1-C4alkyl), —SO2(C1-C4alkyl), or —SO2NR17R18; each of R13 and R14 is independently hydrogen, halogen, unsubstituted or substituted C1-C4alkyl, unsubstituted or substituted C1-C4alkoxy, unsubstituted or substituted C1-C4fluoroalkyl, unsubstituted or substituted C1-C4fluoroalkoxy, unsubstituted or substituted heterocycle, —CN, —OH, —CO2R17, —C(═O)NR17R18, —NR17R18, —NR17C(═O)R18, —NR17C(═O)NHR18, —C(═NOR17)R18, —S(═O)(C1-C4alkyl), —SO2(C1-C4alkyl), or —SO2NR17R18, wherein if any group of R13 and R14 is substituted then the substituted group of R13 and R14 is substituted with 1-4R12; each of R15 and R16 is independently hydrogen, halogen, unsubstituted or substituted C1-C4alkyl, unsubstituted or substituted C1-C4alkoxy, unsubstituted or substituted C1-C4fluoroalkyl, unsubstituted or substituted C1-C4fluoroalkoxy, unsubstituted or substituted heterocycle, —CN, —OH, —CO2R17, —C(═O)NR17R18, —NR17R18, —NR17C(═O)R18, —NR17C(═O)NHR18, —C(═NOR17)R18, —SR17, —S(═O)(C1-C4alkyl), —SO2(C1-C4alkyl), or —SO2NR17R18, wherein if any group of R15 and R16 is substituted then the substituted group of R15 and R16 is substituted with 1-4R12; each of R17 and R18 is independently hydrogen, C1-C4alkyl, C1-C4fluoroalkyl, C1-C4hydroxyalkyl, C1-C4aminoalkyl, or heterocycle; m is 1, 2, 3, or 4; and n is 0, 1, 2, 3, or 4. |
