| 主权项 |
1. A method of treating a patient suffering from a disease for which treatment with cysteamine is indicated comprising administering to the patient an effective amount of a composition comprising a compound of formula I or a disulfide thereof: wherein: R1 and R2 are independently selected from the group consisting of H and C1-5alkyl; or R1 and R2, taken together with the carbon atom to which they are attached, form a 3-, 4-, 5-, 6-, 7-, or 8-membered carbocyclic ring; R3 and R4 are independently selected from the group consisting of H and C1-5alkyl; or R3 and R4, taken together with the carbon atom to which they are attached, form a 3-, 4-, 5-, 6-, 7-, or 8-membered carbocyclic ring; G is selected from the group consisting of —NR5R6 and —CR7R8NR5R6; R5 and R6 are independently selected from the group consisting of H and C1-5alkyl; or R5 and R6, taken together with the nitrogen atom to which they are attached, form a 3-, 4-, 5-, 6-, 7-, or 8-membered heterocyclic ring; R7 and R8 are independently selected from the group consisting of H and C1-5alkyl; or R7 and R8, taken together with the carbon atom to which they are attached, form a 3-, 4-, 5-, 6-, 7-, or 8-membered carbocyclic ring; R2 and R6, taken together with the atoms to which they are attached, form a 4-, 5-, 6-, 7-, 8-, 9-, or 10-membered heterocyclic ring; R4 and R6, taken together with the atoms to which they are attached, form a 4-, 5-, 6-, 7-, 8-, 9-, or 10-membered heterocyclic ring; R2 and R8, taken together with the atoms to which they are attached, form a 3-, 4-, 5-, 6-, 7-, or 8-membered carbocyclic ring; or R2 and R4, taken together with the atoms to which they are attached, form a 3-, 4-, 5-, 6-, 7-, or 8-membered carbocyclic ring; with the proviso that when G is —NH2, at least one of R1, R2, R3, and R4 is other than H. |
