NOVEL ULTRASHORT HYDROPHOBIC PEPTIDES THAT SELF-ASSEMBLE INTO NANOFIBROUS HYDROGELS AND THEIR USES

摘要

The present invention relates to hydrophobic peptides and/or peptidomimetics capable of forming a (nanofibrous) hydrogel and hydrogels comprising said hydrophobic peptides and/or peptidomimetics and to various uses, such as in regenerative medicine, injectable therapies, delivery of bioactive moieties, wound healing, 2D and 3D synthetic cell culture substrate, biosensor development, biofunctionalized surfaces, and biofabrication.

主权项

1. A hydrophobic peptide and/or peptidomimetic capable of forming a hydrogel, the hydrophobic peptide and/or peptidomimetic having the general formula:
Z—(X)a—Z′b wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from the group consisting of aliphatic D- or L-amino acids and aliphatic D- or L-amino acid derivatives, and wherein the overall hydrophobicity decreases from N- to C-terminus; a is an integer selected from 2 to 7, preferably 2 to 6; Z′ is a C-terminal group; and b is 0 or 1.