ACTIVATABLE ANTIBODIES THAT BIND INTERLEUKIN-6 RECEPTOR AND METHODS OF USE THEREOF

摘要

The invention relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically binds to interleukin-6 receptor (IL-6R), and to methods of making and using these anti-IL-6R activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

主权项

1. An activatable antibody that in an activated state binds Interleukin-6 Receptor (IL-6R) comprising:
an antibody or an antigen binding fragment thereof (AB) that specifically binds to IL-6R; a masking moiety (MM) that inhibits the binding of the AB to IL-6R in an uncleaved state; and a cleavable moiety (CM) coupled to the AB, wherein the CM is a polypeptide that functions as a substrate for a protease.