CYCLOPROPANAMINE COMPOUND AND USE THEREOF

摘要

The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, developmental disorders, particularly diseases having intellectual disability (e.g., autistic spectrum disorders, Rett syndrome, Down's syndrome, Kabuki syndrome, fragile X syndrome, Kleefstra syndrome, neurofibromatosis type 1, Noonan syndrome, tuberous sclerosis), neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, spinocerebellar degeneration (e.g., dentatorubural pallidoluysian atrophy) and Huntington's disease), epilepsy (e.g., Dravet syndrome) or drug dependence, and the like. A compound represented by the formula;;wherein each symbol is as defined in the present specification, or a salt thereof.

主权项

1. A compound represented by the formula wherein A is an optionally substituted heterocyclic group, or an optionally substituted hydrocarbon group; B is a ring selected from (1) a 5- or 6-membered aromatic heterocycle optionally fused with an optionally substituted 5- or 6-membered ring, and (2) a benzene ring fused with an optionally substituted 5- or 6-membered ring, wherein the ring represented by B is optionally substituted, and binds, via two adjacent carbon atoms with one atom in between, to a group represented by the formulaand
a group represented by the formula R1, R2, R3 and R4 are each independently a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; A and R1 are optionally bonded with each other to form, together with the adjacent nitrogen atom, an optionally substituted cyclic group; and R2 and R3 are optionally bonded with each other to form, together with the adjacent nitrogen atom, an optionally substituted cyclic group, or a salt thereof.