Methods and Compositions Related To miR-21 and miR-29A, Exosome Inhibition And Cancer Metastasis

摘要

The present invention provides materials and methods related to the discovery that tumor secreted miR-21 and miR-29a can function by binding as ligands to receptors of the Toll-like receptor family, murine TLR7 and human TLR8, in immune cells, triggering a TLR-mediated prometastatic inflammatory response, which leads to tumor growth and metastasis. Thus, by acting as paracrine agonists of TLRs, secreted miRNAs are key regulators of the tumor microenvironment. This mechanism of action of miRNAs is important in the tumor-immune system communication, in tumor growth and spread, and in cancer treatment.

主权项

1. A composition of matter comprising at least one anti-miR-21 inhibitor and at least acid anti-miR-29a inhibitor in at least one pharmaceutically-acceptable carrier or excipient.