SURFACE ENERGY DIRECTED CELL SELF ASSEMBLY

摘要

The present disclosure provides a method of fabricating cell, such as stem cell, arrays on a carrier where the surface energy of the carrier has been modified and patterned so that only areas of low contact angle are wet by a water based cell solution. The patterned cell solution when applied to the carrier surface then self assembles into a 3 dimensional micro pattern on the carrier that mimics the surface topography of mammalian organs.

主权项

1. A method to prepare a substrate containing cells in a predetermined pattern, comprising:
providing a substrate, the surface energy of which is modified to correspond to surface energy of a predetermined liquid composition comprising a population of cells, wherein the surface energy of a portion of the surface of the substrate is modified to provide the predetermined pattern; and applying the predetermined liquid composition to the surface of the substrate.