Device, System and Process for Modification or Concentration of Cell-Depleted Fluid

摘要

A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.

主权项

1. A product concentration device for modification or concentration of a cell-depleted filtrate, said device comprising:
1) a hollow fiber filter element (or module; preferably a cylindrical hollow fiber filter cartridge) said filter element comprising an entrance end and an exit end, said filter element further comprising a plurality (more than one) of filtration retentate chambers, each filtration retentate chamber being an open-ended hollow fiber, wherein each fiber comprises a semi-permeable outer wall, said filter element further comprising a filtrate chamber, said filter chamber comprising a filtrate chamber inner wall and a filtrate chamber outer wall, such that said filtrate chamber encloses said fibers but does not block their open ends, such that the semi-permeable outer walls of the fibers are also part of the filtrate chamber inner wall, said filtrate chamber outer wall optionally comprising pores or outlet(s) for flowing the filtrate from the filtrate chamber to an intermediate or final collection vessel; 2) an alternating flow pump, said pump said pump connected to the exit end of the filter element so as to permit fluid from the pump to enter the filtration retentate chambers and fluid from the retentate chambers to enter the pump (said pump, for example, comprising a pump housing, two chambers, and a diaphragm separating the chambers); 3) A reservoir connected to said filter element entrance end, so that fluid can flow between said reservoir and the retentate filtration chambers; wherein the retentate chamber fibers are disposed in parallel to the center axis of the filter element (the center axis extends through the center of the cylinder from one filter element end to the other, wherein those fibers each have an entrance at the entrance end of the filter element and an exit at the exit end of the filter element.