METHODS OF TREATING CANCER USING ANTI-OX40 ANTIBODIES AND PD-1 AXIS BINDING ANTAGONISTS

摘要

The invention provides methods of treating or delaying progression of cancer in an individual comprising administering to the individual an anti-human OX40 agonist antibody and an anti-PDL1 antibody. In some embodiments, the anti-human OX40 agonist antibody is administered in a dose selected from about 0.8 mg, about 3.2 mg, about 12 mg, about 40 mg, about 80 mg, about 130 mg, about 160 mg, about 300 mg, about 320 mg, about 400 mg, about 600 mg, and about 1200 mg, and the anti-PDL1 antibody is administered at a dose of about 800 mg or about 1200 mg.

主权项

1. A method of treating or delaying progression of cancer in an individual comprising administering to the individual:
(i) an anti-human OX40 agonist antibody at a dose selected from the group consisting of about 0.8 mg, about 3.2 mg, about 12 mg, about 40 mg, about 80 mg, about 130 mg, about 160 mg, about 300 mg, about 320 mg, about 400 mg, about 600 mg, and about 1200 mg, wherein the anti-human OX40 agonist antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:2; (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:3; (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:4; (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:5; (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:6; and (f) HVR-L3 comprising an amino acid sequence selected from SEQ ID NO:7; and (ii) an anti-PDL1 antibody at a dose of about 800 mg or about 1200 mg, wherein the anti-PDL1 antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:196; (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:197; (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:198; (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:199; (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:200; and (f) HVR-L3 comprising an amino acid sequence selected from SEQ ID NO:201; wherein the individual is a human.