METHOD FOR THE VACCINATION AGAINST HIV

摘要

The present invention relates to novel compositions of active agents and methods for the treatment of HIV infection and AIDS. In particular, the present invention relates to novel methods to select HIV infected patients with improved responses to HIV-specific vaccine peptides.

主权项

1. A method for reducing and/or delaying one or more pathological effects of human immunodeficiency virus I (HIV) or for reducing the risk of developing acquired immunodeficiency syndrome (AIDS) in a human infected with HIV, the method comprising the steps of:
a) measuring in a biological sample, such as serum or plasma, from a human infected with HIV the amount of antibodies against one or more epitope of HIV envelope glycoproteins gp120 and/or gp41 in a suitable assay; b) selecting a subgroup of humans from a), wherein the amount of said measured antibodies corresponds to an amount of above background level of uninfected humans, such as above 1 μg/ml of antibodies against Vacc-C5 in serum as measured by an ELISA assay as described in example 33; c) treating said humans infected with HIV selected under b) with one or more peptide(s) to stimulate a cell-mediated immune response and/or a compound that stimulates a humoral response in said human.