| 摘要 |
The present invention relates to compounds of Formula III, Formula 111(a), Formula V, Formula V(a), Formula A, Formula A 1, Formula A2, Formula A 3, or a pharmaceutically acceptable salt thereof that are useful as pharmaceutical agents, individually and/or in a combination with a chemotherapeutic agent: PLX-4032 (vemurafenib), or the catalytic mTOR inhibitor AZD8055, to treat a cancer and/or a cancer metastasis, for example a cancer harboring a BRAF protein kinase mutation and/or a HRAS protein mutation. Also, a method of treating and/or preventing malaria in a subject, the method comprising administering a therapeutically effective amount of a compound of Formula A, Formula A 1, Formula A2, Formula A 3, or a pharmaceutically acceptable salt thereof to the subject in need. |
| 主权项 |
1. A method of treating a cancer, or a cancer metastasis in a subject in need thereof, the method comprising: administering to the subject, a therapeutically effective amount of a compound of Formula A: or a pharmaceutically acceptable salt thereof, wherein:
A is an optionally substituted aryl or optionally substituted cycloalkyl;Z is a 3 to 7 membered heterocycloalkyl;X is H, halogen, or —CF3;nD is 1 to 3;RA is optionally substituted C1-6 alkyl; andRB is H, optionally substituted C1-6 alkyl, or optionally substituted C1-6 alkoxyl. |
