MODULATION OF CYP8B1 FOR THE PREVENTION AND TREATMENT OF LIVER FIBROSIS AND METABOLIC DISORDERS

摘要

Provided are oligomers, methods, uses and pharmaceutical compositions for reducing the expression of Sterol 12-α hydroxylase (Cyp8b1 ) in a cell or tissue with an oligomer described herein in a biologically effective amount sufficient for the treatment of liver fibrosis. The oligomer may be between 4 to 49 nucleobases in length which comprises a contiguous nucleotide sequence of a total of between 4 to 49 nucleotides, wherein the contiguous nucleotide sequence is targeted to hybridize to a portion of SEQ ID NO: 104: wherein the oligomer, when bound to the portion of SEQ ID NO: 104 reduces expression of Sterol 12-α hydroxylase (Cyp8b1 ) in a cell or tissue.