发明名称 |
POLYMERIC NANOPARTICLES FOR PHOTOSENSITIZERS |
摘要 |
Biodegradable polymeric nanoparticles comprising an inner core formed of a photodynamic agent capable of being activated to generate cytotoxic singlet oxygen are prepared. These nanoparticles have anti-cell proliferation activity and are useful in treating both cancerous and non-cancerous conditions including actinic keratosis, psoriasis and acne vulgaris. Preferably, the photodynamic agent is a hypocrellin B derivative while the polymeric nanoparticle comprises polyglycolic acid, polylactic acid or poly(lactide-co-glycolide). Hypocrellin-comprising nanoparticles are demonstrated to be activated by light or hydrogen peroxide. |
申请公布号 |
EP2741775(B1) |
申请公布日期 |
2017.01.04 |
申请号 |
EP20110870680 |
申请日期 |
2011.08.11 |
申请人 |
Quest Pharmatech Inc. |
发明人 |
HADDADI, Azita;MADIYALAKAN, Ragupathy;WOO, Thomas |
分类号 |
A61K41/00;A61K9/00;A61K9/06;A61K9/14;A61K9/51;A61K31/122;A61K47/34;A61P35/00;C07C49/755;C07C49/84 |
主分类号 |
A61K41/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|