| 发明名称 | Methods and tools for identification of RSK/MSK kinase inhibitors | ||
| 摘要 | The present invention concerns 3D-crystals of complexes of ribosomal S6 kinase (RSK) and mitogen- and stress-activated protein kinase (MSK) proteins and their ligands, as well as methods for crystallization, three-dimensional structure determination and structure assisted methods for identifying ligands of said proteins. | ||
| 申请公布号 | US9534209(B2) | 申请公布日期 | 2017.01.03 |
| 申请号 | US201314431008 | 申请日期 | 2013.09.30 |
| 申请人 | Aarhus Universitet;Region Midtjylland | 发明人 | Andersen Jacob Lauwring;Gesser Borbala;Nissen Poul;Iversen Lars |
| 分类号 | C12N9/12;C30B29/58;C30B7/00;C40B30/02;G06F19/12;G06F19/16;G06F19/00 | 主分类号 | C12N9/12 |
| 代理机构 | Dinsmore & Shohl LLP | 代理人 | Dinsmore & Shohl LLP ;Gould Weston |
| 主权项 | 1. A three dimensional crystal of a complex between: a) dimethyl fumarate (DMF) ligand, and b) a polypeptide consisting of the sequence of SEQ ID NO: 1 (C-terminal kinase domain of murine ribosomal S6 kinase 2), wherein said crystal is of a tetragonal space group having unit cell parameters of a=b=47 ű3 Λ, c=292 ű5 Å and α=β=γ=90°±2°. | ||
| 地址 | Aarhus DK | ||