Lyme disease vaccine

摘要

Antigenic polypeptides comprising linear immunodominant epitopes of Borrelia outer surface protein A (OspA) or Borrelia outer surface protein C (OspC) are useful as vaccines against Lyme disease, and as diagnostics for detecting Borrelia infections. The OspA and OspC antigenic polypeptides typically comprise a plurality of peptides representing epitope containing regions from multiple distinct phyletic groups. The antigenic polypeptides may also include epitopes from both Borrelia OspA and Borrelia OspC.

主权项

1. A recombinant or synthetic fusion protein comprising
at least one linear epitope from Borrelia outer surface protein A (OspA), said at least one linear epitope having an amino acid sequence STLTITVNSKKTKDLVFTKE (SEQ ID NO: 1), and one or more linear Borrelia OspA epitopes having an amino acid sequence selected from the group consisting of(SEQ ID NO: 3)STLTISKNRTKTKQLVFTKE,(SEQ ID NO: 9)NTLTVSADSKKIKDFVFLTD,and(SEQ ID NO: 15)KTLTVSADSKKIKDFVFLTD.