| 主权项 |
1. A compound of formula (I) wherein ring A is fused to the 1,1-dioxothiazinone ring and chosen from L is a bond or —(CH2)n— wherein one or more methylene hydrogens is optionally replaced by C1-5alkyl, C2-6alkenyl, C2-6alkynyl or C1-5haloalkyl; n is 1 to 3; Ar is aryl or heteroaryl substituted independently by one or more halogen, C1-6haloalkyl, C1-6haloalkoxy or C1-6haloalkylS(O)m— and Ar is optionally further substituted by C1-6alkyl; m is 0, 1 or 2; each R1, R2 and R3 are independently chosen from hydrogen, halogen, C1-5alkyl, C3-6cycloalkyl, C1-5alkyl-OH, —C(O)OR4, —C(O)NR4R4, C2-6alkenyl, C2-6alkynyl, C1-5haloalkyl, —OR4 —NR4R4, —CN, —SR4, —S(O)2R4, —S(O)2NR4R4, —NHC(O)R4 and —N(C1-4alkyl)C(O)OR4; each R4 is independently hydrogen, or C1-6alkyl; or a pharmaceutically acceptable salt thereof. |
