发明名称 |
Compositions and methods for promoting intestinal stem cell function |
摘要 |
Disclosed herein are novel methods and compositions useful for promoting intestinal stem cell function. The methods and compositions are particularly useful for stimulating the proliferation of and/or self-renewal of intestinal stem cells, as well as for minimizing, preventing, or ameliorating cellular damage resulting from incidental or accidental exposure to radiation (e.g., cancer radiation therapy). |
申请公布号 |
US9532997(B2) |
申请公布日期 |
2017.01.03 |
申请号 |
US201314390731 |
申请日期 |
2013.04.03 |
申请人 |
Whitehead Institute for Biomedical Research |
发明人 |
Katajisto Pekka;Pacold Michael;Sabatini David M.;Yilmaz Omer |
分类号 |
A61K31/675;A61K45/06;A61K31/436;A61K31/7076;A61K31/7088;A61K38/46;A61K31/713 |
主分类号 |
A61K31/675 |
代理机构 |
Morse, Barnes-Brown & Pendleton, P.C. |
代理人 |
Warren, Esq. Lisa M.;Morse, Barnes-Brown & Pendleton, P.C. |
主权项 |
1. A method of stimulating the proliferation and/or self-renewal of one or more intestinal stem cells in mammalian intestinal tissue comprising contacting a population of Paneth cells or Paneth-like cells in the mammalian intestinal tissue with an effective amount of a calorie restriction mimetic, wherein the calorie restriction mimetic comprises an agent that increases the level and/or activity of bone stromal antigen 1 (Bst-1) or a product of Bst-1. |
地址 |
Cambridge MA US |