发明名称 | Dual-action, unnatural proline-rich peptides as antibiotic agents and methods thereof | ||
摘要 | The present invention cationic amphiphilic polyproline helices (CAPHs) compounds having increased hydrophobicity and cellular internalization as antimicrobial agents. Antimicrobial compositions and methods of using the same are also provided. | ||
申请公布号 | US9533975(B2) | 申请公布日期 | 2017.01.03 |
申请号 | US201514702530 | 申请日期 | 2015.05.01 |
申请人 | Purdue Research Foundation | 发明人 | Chmielewski Jean Anne |
分类号 | C07K7/06;C07D405/14;A61K47/48;A61K31/7036;A61K49/00;C07K5/083;A61K38/00 | 主分类号 | C07K7/06 |
代理机构 | Faegre Baker Daniels LLP | 代理人 | Faegre Baker Daniels LLP |
主权项 | 1. A compound having the structure: wherein R1 is an alkyl substituent, the alkyl substituent being straight, branched or cyclic, an aryl substituent, an acyl substituent, an acetyl substituent, a dye, a fluorophore, a conjugating agent, an intracellular directing group or an antimicrobial agent; wherein R2 and R3 are each independently, a hydrophobic alkyl or aryl moiety; and wherein n is from about 3 to about 10. | ||
地址 | West Lafayette IN US |