Antibodies to TTR and methods of use

摘要

The disclosure pertains to antibodies and binding fragments thereof that specifically binds all or part of EHAEVVFTA. Also provided are isolated peptides, isolated nucleic acids, immunogens, compositions, immunoassays and kits and method of using said reagents to detect misfolded TTR.

主权项

1. A conformation specific antibody or binding fragment thereof that specifically binds all of EHAEVVFTA (SEQ ID NO: 1), wherein the antibody or binding fragment thereof is capable of binding to TTR amyloid fibrils as found in situ in a biological sample obtained from a subject.