Proteins and nucleic acids useful in vaccines targeting <i>Staphylococcus aureus </i>

摘要

Disclosed are novel immunogenic proteins derived from Staphylococcus aureus, as well as methods for their use in conferring protective immunity against S. aureus infections. Also disclosed are nucleic acids encoding the proteins and methods of use of these nucleic acids.

主权项

1. A pharmaceutical composition comprising a polypeptide consisting of
a) an amino acid sequence consisting of amino acid residues 28-820 of SEQ ID NO: 13, or b) an amino acid sequence having a sequence identity of at least 80% with the amino acid sequence of a) and having the same length as the amino acid sequence of a), or c) an amino acid sequence consisting of at least 35 contiguous amino acid residues of 28-820 of SEQ ID NO: 13, or d) an amino acid sequence of a), b) or c), which is fused or conjugated to an immunogenic carrier molecule or a tag, said pharmaceutical composition further comprising an immunological adjuvant and a pharmaceutically acceptable carrier, vehicle or diluent, and said polypeptide being antigenic in a mammal.