发明名称 |
Aprepitant L-proline solvates—compositions and cocrystals |
摘要 |
Aprepitant L-proline solvate compositions and aprepitant L-proline solvate cocrystals are disclosed as well as pharmaceutical compositions containing them. The compositions and cocrystals of the invention are: 1:1:1 aprepitant L-proline methanol composition; a 1:1:1 aprepitant L-proline methanol cocrystal; a 1:1:1:1 aprepitant L-proline ethanol composition; a 1:1:1 aprepitant L-proline ethanol cocrystal; 1 1:1:1 aprepitant L-proline n-propanol composition; and a 1:1:1 aprepitant L-proline n-propanol cocrystal: The aprepitant L-proline solvate compositions or cocrystals may be used in the same way as aprepitant to treat or prevent disorders relating to emesis, a neuropsychiatric disease, an inflammatory disease, pain, cancer, a skin disease, itch a respiratory disease, or an addiction. |
申请公布号 |
US9532993(B2) |
申请公布日期 |
2017.01.03 |
申请号 |
US201214360071 |
申请日期 |
2012.11.21 |
申请人 |
NUFORMIX LIMITED |
发明人 |
Holland Joanne;Frampton Christopher;Chorlton Alan;Gooding Daniel |
分类号 |
C07D413/06;A61K31/5377;A61K31/401;C07D405/06;A61K47/10 |
主分类号 |
C07D413/06 |
代理机构 |
J. A. Lindeman & Co., PLLC |
代理人 |
J. A. Lindeman & Co., PLLC |
主权项 |
1. An aprepitant L-proline solvate composition selected from a 1:1:1 aprepitant L-proline methanol composition, a 1:1:1 aprepitant L-proline ethanol composition, and a 1:1:1 aprepitant L-proline n-propanol composition. |
地址 |
GB |