Assay for diagnosing <i>Streptococcus pneumoniae</i>

摘要

Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.

主权项

1. A method for detecting a past infection or active infection by Streptococcus pneumoniae in a subject, wherein said infection is determined by contacting a biological sample of the subject with PcpA and Ply antigens and detecting binding of antibodies against PcpA and Ply in the biological sample.