| 发明名称 |
Immunoregulation by anti-ILT5 antibodies and ILT5-binding antibody fragments |
| 摘要 |
Disclosed herein are methods of using anti-ILT5 antibodies and ILT5-binding fragments thereof for the treatment of various diseases and for use as immunostimulatory adjuvants. |
| 申请公布号 |
US9534051(B2) |
申请公布日期 |
2017.01.03 |
| 申请号 |
US201414462596 |
申请日期 |
2014.08.19 |
| 申请人 |
Merck Sharp & Dohme Corp. |
发明人 |
Apostolou Irina;Ponath Paul;Ponte Joe;Rosenzweig Michael;Vaickus Lou |
| 分类号 |
C07K16/28;A61K39/395;A61K35/00;A61K35/15;A61K39/00 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of inhibiting proliferation in a T cell, the method comprising contacting the T cell with an antigen and an antigen presenting cell (APC) that has been contacted with a crosslinked anti-Immunoglobulin-like transcript 5 (ILT5) antibody or a crosslinked ILT5-binding fragment of the antibody. |
| 地址 |
Rahway NJ US |
