| 发明名称 | Methods and compositions for diagnosis of inflammatory liver disease | ||
| 摘要 | The present disclosure provides methods and compositions that find use in facilitating a diagnosis of inflammatory liver disease in a subject. The methods and compositions generally involve detection of eotaxin-3 (E3) levels, either alone or with levels of eotaxin-1 (E1), and optionally, with levels of CCL22 and, further optionally, with levels of IL15. These levels can be used to facilitate a diagnosis of a liver disease of at least one of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), and/or to facilitate a differential diagnosis between AIH, PBC, and PSC. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject. | ||
| 申请公布号 | US9535071(B2) | 申请公布日期 | 2017.01.03 |
| 申请号 | US201314423998 | 申请日期 | 2013.09.06 |
| 申请人 | The Governors of the University of Alberta;Medizinische Hochschule Hannover | 发明人 | Landi Abdolamir;Houghton Michael;Tyrrell D. Lorne;Lankisch Tim;Weismueller Tobias;Manns Michael |
| 分类号 | C40B30/04;G01N33/48;G01N33/68;G06F19/24;G06F19/00 | 主分类号 | C40B30/04 |
| 代理机构 | Bozicevic, Field & Francis LLP | 代理人 | Francis Carol L.;Bozicevic, Field & Francis LLP |
| 主权项 | 1. A method detecting eotaxin-3 in a subject, the method comprising: obtaining a biological sample obtained from a subject suspected of having at least one of autoimmune hepatitis (AIH), primary sclerosing cholangitis (PSC), and primary biliary cirrhosis (PBC); and detecting eotaxin-3 (E3) in the biological sample by contacting the biological sample with an anti-E3 antibody and detecting binding between E3 and the antibody. | ||
| 地址 | Edmonton CA | ||