Medical devices containing therapeutic agents

摘要

The present invention pertains to implantable or insertable medical devices which comprise a substrate and one or more therapeutic-agent-containing regions contain one or more therapeutic agents. In various aspects of the invention, one or more characteristics of such therapeutic-agent-containing regions are controlled. Further aspects of the invention relate to methods of forming such devices and to methods of using such devices.

主权项

1. A medical device comprising an inorganic substrate, a discontinuous layer of therapeutic-agent containing material that comprises a therapeutic agent, said discontinuous layer comprising a first area corresponding to a plurality of regions of said therapeutic-agent-containing material which cover the substrate and a second area which does not cover the substrate, and an inorganic nanoporous layer disposed over the therapeutic-agent-containing layer, said inorganic nanoporous layer being in contact with said therapeutic-agent-containing material in said first area and in contact with said substrate in said second area, wherein said regions of said therapeutic-agent-containing material are not disposed within depressions in the surface of a substrate, and wherein said regions of said therapeutic-agent-containing material are in the form of discrete flattened particles.