Described herein are compositions composed of peptide nucleic acid strands. In some aspects the peptide nucleic acid strands are complementary to at least a portion of another peptide nucleic acid strand that may have one or more gamma substituents, where the ratio of PNA strands is least 1:1. Certain gamma substituents are capable of effecting attachment of a PNA strand to a cell. The disclosure also concerns construction of nanostructure platforms and vaccines and use of the inventive compositions in inhibiting disease states in mammals.
申请公布号
EP3096796(A1)
申请公布日期
2016.11.30
申请号
EP20150701925
申请日期
2015.01.16
申请人
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人
APPELLA, Daniel H.;DIX, Andrew V.;ENGLUND, Ethan;GEORGE ROSENKER, Kara