A FACILE ENZYMATIC SYNTHESIS OF GALACTOSYL BETA1,3 GLYCALS:A GALACTOSIDASE INHIBITOR AND KEY INTERMEDIATES FOR THE SYNTHESIS OF LEA,SIALYL LEA AND ANALOGS

摘要

An enzymatic process is disclosed for the preparation of galactosyl beta 1,3glycal disaccharides such as Gal beta 1,3Glucal, an intermediate useful in Lea preparation and an inhibitor of beta -galactosidase. The process utilizes beta -galactosidase, an enzyme usually used for bond breaking, to form a bond between a galactoside and a glucal such as glycal, a 6-O-C1-C6 acylglucal or 6-O-C1-C6 acetylgalactal.