发明名称 |
DERMASEPTIN-TYPE AND PISCIDIN-TYPE ANTIMICROBIAL PEPTIDES |
摘要 |
Antimicrobial agents, including antimicrobial peptides (AMPs) and uses thereof. Compositions and methods of using dermaseptin-type and piscidin-type antimicrobial peptides that demonstrate activity and improved therapeutic indices against microbial pathogens. The peptide compositions demonstrate the ability to not only maintain or improve antimicrobial activity against bacterial pathogens including Gram-negative microorganisms Acinetobacter baumannii and Pseudomonas aeruginosa, but also significantly decrease hemolytic activity against human red blood cells. Specificity determinants within the AMPS change selectivity from broad spectrum antimicrobial activity to AMPS with gram-negative selectivity. |
申请公布号 |
EP3096616(A2) |
申请公布日期 |
2016.11.30 |
申请号 |
EP20150740068 |
申请日期 |
2015.01.26 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODYCORPORATE |
发明人 |
JIANG, Ziqing;HODGES, Robert, S.;GERA, Lajos;MANT, Colin, T. |
分类号 |
A01N37/18;A61K38/00;A61K38/04;A61K38/40;A61K47/48;C07K5/00;C07K14/79 |
主分类号 |
A01N37/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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