发明名称 |
SDF-1 DELIVERY FOR TREATING ISCHEMIC TISSUE |
摘要 |
Provided are methods of treating a cardiomyopathy in a subject by administering directly to, or expressing locally in, a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of stromal-cell derived factor-1 (SDF-1 ) effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification. Also provided are methods of treating critical limb ischemia in a subject by administering a DNA plasmid encoding human SDF-1 by direct injection into the affected limb. |
申请公布号 |
EP2970941(A4) |
申请公布日期 |
2016.11.30 |
申请号 |
EP20140762452 |
申请日期 |
2014.03.15 |
申请人 |
THE CLEVELAND CLINIC FOUNDATION;JUVENTAS THERAPEUTICS, INC. |
发明人 |
PENN, MARC, S.;ARAS, RAHUL;PASTORE, JOSEPH;MILLER, TIMOTHY, J. |
分类号 |
A61K48/00;C07K14/52 |
主分类号 |
A61K48/00 |
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