| 摘要 |
Methods and apparatuses for creating oligos with a targeted nucleotide type distribution, and for restoring the initially encoded data, are presented. A method of creating oligos with a targeted of nucleotide type distribution, represented by sequences of quaternary code symbols, comprises -acquiring (14) an unmodified sequence, -selecting (15) a modification rule from a set of different modification rules, - generating (16) a modified sequence from the unmodified sequence, and -creating (17) an oligo comprising a nucleotide sequence corresponding to the modified symbol sequence. The corresponding method of determining unmodified code symbol sequences from oligos generated from modified code symbol sequences comprises - determining (64) a modified code symbol sequence by sequencing a corresponding oligo, -determining (65) a selected modification rule of a rule set that has been applied to generate the modified sequence, and -generating (66) an unmodified sequence from the modified sequence using a reverse modification rule. |
