发明名称 BRIDGED PIPERIDINE DERIVATIVES
摘要 The present invention relates to compounds of formulawherein hetaryl I, hetaryl II, R, R, R, Y, p, m, n, o are as defined in the claims; or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.
申请公布号 EA025035(B1) 申请公布日期 2016.11.30
申请号 EA20130091209 申请日期 2012.02.28
申请人 F. HOFFMANN-LA ROCHE AG 发明人 BAUMANN Karlheinz;GREEN Luke;LIMBERG Anja;LUEBBERS Thomas;THOMAS Andrew
分类号 C07D471/04;A61K31/4196;A61P25/00;C07D519/00 主分类号 C07D471/04
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