发明名称 |
NOVEL VACCINES AGAINST HPV AND HPV-RELATED DISEASES |
摘要 |
Embodiments relate to novel vaccines against human papillomavirus (HPV) and HPV-related diseases, including multiple types of cancers. The HPV vaccines are composed of anti-human dendritic cell (DC) surface receptor antibodies, including CD40, and E6/7 proteins of HPV 16 and 18. The technology described is not limited to making vaccines against HPV16- and HPV18-related diseases and can be applied to making vaccines carrying E6/7 from any type of HPV. The HPV vaccines described can target DCs, major and professional antigen presenting cells (APCs), and can induce and activate potent HPV E6/7-specific and strong CD4+ and CD8+ T cell responses. The HPV vaccines can be used for the prevention of HPV infection and HPV-related diseases as well as for the treatment of HPV-related diseases, including cancers. |
申请公布号 |
EP3094652(A1) |
申请公布日期 |
2016.11.23 |
申请号 |
EP20150735460 |
申请日期 |
2015.01.13 |
申请人 |
BAYLOR RESEARCH INSTITUTE |
发明人 |
OH, SANGKON;ZURAWSKI, SANDRA;ZURAWSKI, GERARD |
分类号 |
C07K16/28;A61K39/12;A61K39/395;C07K16/08;C07K16/46 |
主分类号 |
C07K16/28 |
代理机构 |
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