发明名称 |
1 -(TRIAZIN-3-YI_/PYRIDAZIN-3-YL)-PIPER(-AZINE)IDINE DERIVATIVES AND COMPOSITIONS THEREOF FOR INHIBITING THE ACTIVITY OF SHP2 |
摘要 |
The present invention relates to compounds of formula I: in which Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2. |
申请公布号 |
EP3094629(A1) |
申请公布日期 |
2016.11.23 |
申请号 |
EP20150703106 |
申请日期 |
2015.01.16 |
申请人 |
NOVARTIS AG |
发明人 |
CHEN, ZHUOLIANG;DORE, MICHAEL;FORTANET, JORGE GARCIA;KARKI, RAJESH;KATO, MITSUNORI;LAMARCHE, MATTHEW J.;PEREZ, LAWRENCE BLAS;WILLIAMS, SARAH;SENDZIK, MARTIN |
分类号 |
C07D249/14;A61K31/495;A61P35/04;C07D241/26 |
主分类号 |
C07D249/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|