ALLOSTERIC HEMOGLOBIN MODIFIERS WITH NITRIC OXIDE RELEASING MOIETY
摘要
Allosteric hemoglobin (Hb) modifiers of hemoglobin which contain nitric oxide (NO) moieties allowing for the release of NO in vivo. The compounds retain the oxygen delivery capability of the allosteric hemoglobin modifier to bind Hb and enhance Hb's ability to deliver oxygen to cells and tissues, and also release NO from the NO moiety. Methods of delivering oxygen and/or NO to cells and tissues are also provided.
申请公布号
EP3092213(A1)
申请公布日期
2016.11.16
申请号
EP20140874450
申请日期
2014.12.22
申请人
VIRGINIA COMMONWEALTH UNIVERSITY
发明人
SAFO, MARTIN K.;DANSO-DANQUAH, RICHMOND;GHATGE, MOHINI;VENITZ, JURGEN;MANGINO, MARTIN;WARD, KEVIN R.