| 发明名称 |
AN IMPROVED PROCESS FOR THE PREPARATION OF BENDAMUSTINE HYDROCHLORIDE |
| 摘要 |
The present invention relates to an improved process for the synthesis of bendamustine, in particular, bendamustine hydrochloride of the formula (VI) and its intermediate 1-methyl-5-[bis(2-chloroethyl)amino]-1H-benzimidazol-2-yl]lithium butanoate of formula (V), both having a purity of ≧99%, which is simple, convenient, economical, does not use hazardous chemicals and is industrially viable. |
| 申请公布号 |
EP2760842(B1) |
申请公布日期 |
2016.11.16 |
| 申请号 |
EP20120762073 |
申请日期 |
2012.07.31 |
| 申请人 |
FRESENIUS KABI ONCOLOGY LTD |
发明人 |
MISHRA, BHUWAN BHASKAR;KACHHADIA, NIKUNJ SHAMBHUBHAI;TOMAR, VINOD SINGH;LAHIRI, SASWATA |
| 分类号 |
C07D235/16;A61K31/4184;A61P35/00 |
主分类号 |
C07D235/16 |
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