发明名称 |
3,5-(UN)SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE, 1H-PYRAZOLO[3,4-B]PYRIDINE AND 5H-PYRROLO [2-,3-B]PYRAZINE DUAL ITK AND JAK3 KINASE INHIBITORS |
摘要 |
The present invention relates to compounds described by Formula I: salts thereof, their synthesis, and their use as ITK and JAK3 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and or disorders such disease associated with abnormal cell growth such as autoimmune, inflammation, rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis, ulcerative colitis, psoriatic arthritis, psoriasis, Crohn's, metabolic and cancer diseases. The present invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions and processes for preparing the compounds of the invention. |
申请公布号 |
EP2986300(A4) |
申请公布日期 |
2016.11.16 |
申请号 |
EP20140784823 |
申请日期 |
2014.04.17 |
申请人 |
ARRIEN PHARMAEUTICALS LLC |
发明人 |
VANKAYALAPATI, HARIPRASAD;YERRAMREDDY, VENKATAKRISHNAREDDY;GANGIREDDY, PARAMAREDDY;APPALANENI, RAJENDRA, P. |
分类号 |
A61K31/4985;C07D487/04 |
主分类号 |
A61K31/4985 |
代理机构 |
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