发明名称 |
GATA-3 INHIBITORS FOR USE IN THE TREATMENT OF TH2-DRIVEN ASTHMA |
摘要 |
The invention relates to GATA-3 inhibitors for use in the treatment of Th2-driven asthma, in particular to DNAzymes directed at GATA-3 for use in the treatment of a patient suffering from allergic asthma, wherein the patient is characterized by (i) a blood eosinophil count of 3% or more, particularly of 4% or more, more particularly of 5% or more; and/or (ii) blood eosinophil count of 350 x 10 6 / L or more, particularly of 450 x 10 6 / L or more; and/or (iii) fractional expiratory nitric oxide of 40 ppb or more. |
申请公布号 |
EP3093022(A1) |
申请公布日期 |
2016.11.16 |
申请号 |
EP20150001472 |
申请日期 |
2015.05.15 |
申请人 |
STERNA BIOLOGICALS GMBH & CO. KG |
发明人 |
BILLE, JOACHIM;RENZ, JONAS |
分类号 |
A61K31/7088;A61P11/06;C12N15/113 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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地址 |
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