SYSTEM AND METHOD FOR TRANSFORMING AND COMPRESSING GENOMICS DATA

摘要

This invention relates to the quality scores of bases produced from high throughput genomic sequencing, in particular to transforming the quality scores for improved compressibility. A method for transforming these quality scores is described whereby a quality score is modified by utilising a Bayesian model based on Coding Theory combined with search results from a genomic corpus. A related method is described for efficient searching for a Read in a genomic corpus so as to find all matching symbols up to a given Hamming-distance or Edit-distance.