| 发明名称 |
RECOMBINANT OBLIGATE ANAEROBIC GRAM-POSITIVE BACTERIA (As amended) |
| 摘要 |
An object of the present invention is to effectively induce cancer cell apoptosis using the anti-TRAIL-R1 antibody(ies) and the anti-TRAIL-R2 antibody(ies) and to reduce the toxicity imposed on normal cells. The present invention relates to recombinant obligate anaerobic Gram-positive bacteria that include a nucleic acid encoding a fusion protein having 3 or more anti-TRAIL-R1 single-chain antibodies and/or 3 or more anti-TRAIL-R2 single-chain antibodies, in an expressible state. |
| 申请公布号 |
US2016326256(A1) |
申请公布日期 |
2016.11.10 |
| 申请号 |
US201415110131 |
申请日期 |
2014.12.24 |
| 申请人 |
TEIKYO HEISEI UNIVERSITY |
发明人 |
NISHIKAWA Takeshi;TAIRA Yuichiro;TAIRA Ikuko;ISHIDA Isao |
| 分类号 |
C07K16/28;C12N15/74 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. Recombinant obligate anaerobic Gram-positive bacteria comprising a nucleic acid encoding a fusion protein comprising a signal peptide and 3 or more anti-TRAIL-R1 single-chain antibodies and/or 3 or more anti-TRAIL-R2 single-chain antibodies, in an expressible state. |
| 地址 |
Tokyo JP |
