CYCLOHEXYL SULFONE ROR GAMMA MODULATORS

摘要

Described are RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.;

主权项

1. The compound having the following formula (I):or a stereoisomer or pharmaceutically-acceptable salt thereof, wherein
R1 and R1′ are, independently at each occurrence, hydrogen, halo, CF3, OCF3, CN, NO2, —(CH2)rORb, —(CH2)rS(O)pRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)Rc, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R11, —S(O)pNR11R11, —NRbS(O)pRc, C1-6 alkyl substituted with 0-3 Ra, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 Ra, C2-6 alkynyl substituted with 0-3 Ra, (CH2)r-3-14 membered carbocycle substituted with 0-3 Ra, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Ra; R2 is independently at each occurrence, hydrogen, ═O, —(CH2)rOR2b, —(CH2)rC(O)R2b, —(CH2)rOC(O)OR2b, —(CH2)rOC(O)NR11R11, —(CH2)rNR2bC(O)R2c, —(CH2)rNR2bC(O)OR2, —(CH2)rNR2bC(O)NR11R11, —(CH2)rNR11R11, —NR2bS(O)pRc, (CH2)rNR2bS(O)pNR11R11, C1-6 alkyl, —(CH2)r-3-10 membered carbocycle substituted with 0-3 R2a or —(CH2)r-4-10 membered heterocycle comprising carbon atoms, and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 R2a; or one R2 together with an R2 on an adjacent carbon combine to form a fused ring substituted with 0-3 R2a wherein the fused ring is selected from 3-10 membered carbocycle substituted with 0-3 R2a, or 4-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 R2a; R2a is, independently at each occurrence, hydrogen, ═O, halo, OCF3, CN, NO2, —(CH2)rORb, —(CH2)rS(O)pRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)Rc, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R11, —S(O)pNR11R11, —NRbS(O)pRc, C1-6 alkyl substituted with 0-3 Ra, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 Ra, C2-6 alkynyl substituted with 0-3 Ra, (CH2)r-3-14 membered carbocycle substituted with 0-3 Ra, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Ra; R2b is, independently at each occurrence, hydrogen, CF3, —(CH2)rORb, —(CH2)rS(O)pRb, —(CH2)rC(O)R1d, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)R1c, —(CH2)rNRbC(O)ORc, —(CH2)rNRbC(O)NR11R11, —(CH2)rS(O)2NR11R11, —(CH2)rNRbS(O)2Rc, C1-6 alkyl substituted with 0-2 Ra, C1-6 haloalkyl, —(CH2)r-3-14 membered carbocycle substituted with 0-3 Ra, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-2 Ra; R2c is, independently at each occurrence, hydrogen, C1-6 alkyl substituted with 0-3 Ra, C2-6 alkenyl substituted with 0-3 Ra, C3-10 cycloalkyl substituted with 0-3 Ra, C6-10 aryl substituted with 0-3 Ra, or —(CH2)r-5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, substituted with 0-3 Ra; R2d is, independently at each occurrence, hydrogen, C1-6 alkyl substituted with 0-2 Rd, C1-6 haloalkyl, C(O)NR11R11, C3-6 cycloalkyl substituted with 0-2 Rd, or (CH2)r-phenyl substituted with 0-2 Ra, a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 Ra; R3 is selected from hydrogen, halo, N3, CN, —(CH2)rOR3b, —(CH2)rNR11R11, C1-6 alkyl substituted with 0-3 R3a, and C3-10 cycloalkyl substituted with 0-3 R3a; 4-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, substituted with 0-3 Ra, or together with the carbon atoms to which they are attached, one R3 combines with a second R3 located on an adjacent atom to form a 5-7 membered carbocycle or a 5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatom selected from N, O and S(O)p, each optionally substituted with 0-3 R3a; R3a is, independently at each occurrence, hydrogen, ═O, halo, OCF3, OCHF2, CF3, CHF2, CN, NO2, —(CH2)rORb, —(CH2)rS(O)pRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)Rc, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R11, —S(O)pNR11R11, —NRbS(O)pRc, C1-6 alkyl substituted with 0-3 Ra, C2-6 alkenyl substituted with 0-3 Ra, C2-6 alkynyl substituted with 0-3 Ra, C1-6 haloalkyl, —(CH2)r-3-14 membered carbocycle substituted with 0-3 Ra, or a —(CH2)r-5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Ra; R3b is, independently at each occurrence, hydrogen, CF3, —(CH2)rORb, —(CH2)rS(O)pRb, —(CH2)rC(O)R1d, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)R1c, —(CH2)rNRbC(O)ORc, —(CH2)rNRbC(O)NR11R11, —(CH2)rS(O)2NR11R11, —(CH2)rNRbS(O)2Rc, C1-6 alkyl substituted with 0-3 Ra, C1-6 haloalkyl, —(CH2)r-3-14 membered carbocycle substituted with 0-3 Ra, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Ra; R11 is, independently at each occurrence, hydrogen, C1-6 alkyl substituted with 0-3 Rf, CF3, C3-10 cycloalkyl substituted with 0-3 Rf, —(CH)r-phenyl substituted with 0-3 Rd, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rd; or one R11 and a second R11, both attached to the same nitrogen atom, combine to form a heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rd; Ra is, independently at each occurrence, hydrogen, ═O, halo, OCF3, CF3, CHF2, CN, NO2, —(CH2)rORb, —(CH2)rS(O)pRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)Rc, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R11, —S(O)pNR11R11, —NRbS(O)pRc, C1-6 alkyl substituted with 0-3 Rf, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 Ra, C2-6 alkynyl substituted with 0-3 Ra, —(CH2)r-3-14 membered carbocycle, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rf; Rb is, independently at each occurrence, hydrogen, C1-6 alkyl substituted with 0-3 Rd, C1-6 haloalkyl, C3-6 cycloalkyl substituted with 0-3 Rd, —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rf, or —(CH2)r-6-10 carbocycle substituted with 0-3 Rd; Rc is, independently at each occurrence, C1-6 alkyl substituted with 0-3 Rf, —(CH2)r—C3-6 cycloalkyl substituted with 0-3 Rf, or —(CH2)r-phenyl substituted with 0-3 Rf; Rd is, independently at each occurrence, hydrogen, ═O, halo, OCF3, CF3, CN, NO2, —ORe, —(CH2)rC(O)Rc, —NReRe, —NReC(O)ORc, C(O)NReRe, —NReC(O)Rc, CO2Rc, —NReSO2Rc, SO2Rc, C1-6 alkyl substituted with 0-3 Rf, C3-6 cycloalkyl substituted with 0-3 Rf, —(CH2)r-phenyl substituted with 0-3 Rf or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rf; Re is, independently at each occurrence, selected from hydrogen, C(O)NRfRf, C1-6 alkyl, C3-6 cycloalkyl, or —(CH2)r-phenyl substituted with 0-3 Rf; Rf is, independently at each occurrence, hydrogen, ═O, halo, CN, NH2, NH(C1-6 alkyl), N(C1-6 alkyl)2, SO2(C1-6 alkyl), CO2H, CO2(C1-6 alkyl), OH, C3-6 cycloalkyl, CF3 or O(C1-6 alkyl); or Rf is, independently at each occurrence, an optionally substituted —(CH2)r-5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O), phenyl or C3-6 cycloalkyl, each group optionally substituted with halo, CN, CF3, C1-6 alkyl or O(C1-6 alkyl); q and n are independently selected from 0, 1, 2 and 3; p is 0, 1, or 2; and r is 0, 1, 2, 3, or 4.