COMPOSITION COMPRISING HYALURONIC ACID AND MEPIVACAINE

摘要

Compositions and methods for the surface appearance of the skin a subject are provided. An injectable composition comprising at least hyaluronic acid or a salt thereof; and an effective amount of at least mepivacaine or a salt thereof are provided. The hyaluronic acid optionally has an average molecular weight ranging from 50,000 to 10,000,000 Daltons, and may be crosslinked hyaluronic acids, non-crosslinked hyaluronic acids, or a combination, in some embodiments. The compositions and methods of the present invention are useful for treating and preventing the cutaneous signs of chronological aging and/or induced by external factors such as stress, air pollution, tobacco or prolonged exposure to ultraviolet (UV) exposure, impaired surface appearance of the skin, impaired viscoelastic or biomechanical properties of the skin, and/or the long-lasting filling of volume defects of the skin.

主权项

1. A method comprising:
treating (i) skin surface appearance,
(ii) cutaneous signs of chronological aging and/or signs induced by external factors such as stress, air pollution, tobacco or prolonged exposure to ultraviolet (UV) exposure,(iii) impaired surface appearance of the skin,(iv) impaired viscoelastic or biomechanical properties of the skin,(v) skin volume defects, and/or(vi) deficiencies and defects in gingival architecture and bony tissue by injecting a single sterile, injectable composition into a patient in need thereof, wherein: the single sterile, injectable composition comprises:
(a) an effective amount of hyaluronic acid or a salt thereof; and(b) mepivacaine or a salt thereof as an anesthetic agent at a concentration ranging from 0.05 to 3 wt % of an overall weight of the single, sterile injectable composition.