POLYMERIC NANOCARRIERS WITH LIGHT-TRIGGERED RELEASE MECHANISM

摘要

Near infrared radiation at a wavelength that induces resonance in water is used to remotely activate thermal plasticization of polymeric particles to trigger the release of encapsulated molecules from the particles. Nanocarriers formed from biocompatible hydrophilic polymers may be used to deliver encapsulated molecules to tissue with a reversible transition that allows repeated activations for extended release of the payload.

主权项

1. A method for delivering a payload, comprising:
encapsulating the payload in a nanocarrier comprising a hydrophilic polymer having no inherent light sensitivity; hydrating the polymer to form nanodomains of water; exposing the nanocarrier to light having a wavelength adapted to induce resonant photon interactions with the water to locally heat the polymer to induce a phase change in the polymer whereby the payload diffuses out of the nanocarrier.